When it comes to blood boosting and treatment of anemia, justicia carnea has proven beyond doubt to be an effective remedy. Keep an eye out for glasshouse red spider mite and glasshouse whitefly. Ewe eje is an age-old herb medically proven to act as a blood tonic which can be attributed to its nutritional composition. The result from the kidney histology could be due to the presence of active secondary metabolites and daily dosing of the extract. There should be further studies on the antidepressant activity of justicia carnea leaves. Photomicrograph of a liver sections stained with Haematoxylin and Eosin (Mag. 5. 400). This lends the plant some interesting names such as Blood of Jesus plant and Hospital too far. Justicia Carnea; Blood-Boosting Green Plant That Turns Hot Water Red! Tissues were stained with haematoxylin and eosin, mounted on glass slides and examined under a standard light microscope. 2008;108(9):14807. It is not. PubMed Grows up to 4-6 ft. tall (120-180 cm) and 2-3 ft. wide (60-90 cm). Effects of kolaviron on hepatic oxidative stress in streptozotocin induced diabetes. Uses, Benefits, Cures, Side Effects, Nutrients in Justicia Betonica. This is in agreement with study of Anthonia et al., [21] who obtained LD50 above 5000mg/kg for aqueous extracts of J. carnea leaf. In traditional medicine, justicia carnea is used in treating hepatitis. The appropriate dose of Justicia pectoralis depends on several factors such as the user's age, health, and several other conditions. This is attributed to the anti-hyperlipidaemic properties of the plant. How long does it take for Aju mbaise to work. W Afr J Biol Sci. This may be because of its hepatoprotective activity. This research focused on the safety and in vivo antioxidant status of healthy albino rats exposed to J. carnea leaf ethanol extract. The findings back up local assertions that they can be. The effect of the ethanol extract of Justicea carnea (JC) leaves in phenylhydrazine induced-anemia albino rats on haematological and lipid profile parameters was investigated. Luckily, the unique flowers of Jacobinia carnea and its foliage are free from major pest and disease concerns. It has already been pointed out that this plant is used traditionally to boost blood production among the people of southern Nigeria. Wash the Justicia carnea leaves thoroughly to eliminate all forms of insects and dust. Sample (or standard solution) (0.01ml) was mixed with diluted (1:4v/v distilled water) biuret reagent (100mM sodium hydroxide, 16mM sodium-potassium tartrate, 15mM potassium iodide and 6mM copper sulphate). 7 Potential Health Benefits Of Justicia Carnea (Ewe Eje) J Ethnopharmacol 1999;64(3):265-270. Daily intake of the Ewe eje or ajeri can increase the absorption of iron and vitamins, Uses and health benefits of Ewe eje (Justicia carnea leaf). OTHER NAME(S): Achille Millefeuille, Achille Mille-Feuille, Ana. J Am Diet Assoc. 1978;52:30210. For a few weeks, the cutting should be watered every day to promote root development. The liver and kidneys were excised and rinsed immediately in a normal saline (0.9% Nacl) to remove blood stain, dried between layers of Whatman filter paper, weighed and homogenized to obtain the supernatant for biochemical analysis. The perennial plant puts on a never-ending show of radiant flowers from early spring to fall. Niger J Physiol Sci. In some areas, the plant may tolerate temperatures as low as 50 degrees Fahrenheit (10 C). Emmanuel Sina Akintimehin. Mounanga MB, Mewonob L, Angone SA. A cup of ewe eje extract in the morning will provide you with energy needed to pull through the days activities. Anti-obesity, antioxidant and in silico evaluation of Justicia carnea All rights reserved. The kidney of rats treated with doses of J. carnea ethanol extract revealed dose dependent degree of renal injury (Fig. Olumese FE, Onoagbe IO, Eze GI, Omoruyi FO. The Health benefit of Ewe eje (Justicia carnea leaf) are highlighted in this article. -Amylase binding-interaction with JCAE was also investigated using fluorescence spectroscopy and molecular docking. Treatments of experimental animals were in accordance with the Principle of Laboratory Animal Care manual guide of National Institute of Health [14] as approved by the Institution Research Ethics committee. Packed cell volume (PCV) and mean corpuscular volume (MCV) in treated rats with JCEE were statistically unperturbed compared to the control. Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser J. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Ogwu obara is commonly used in making porridge yam, and soups. https://doi.org/10.4314/njps.v19i1.32627. 50mg/kg-1200mg/kg treatment relative to control treatment showed varied degree of renal injury that is dose dependent. Not sure which Justicia to pick?Compare All Justicia. Some people would rather chew the leaves, while others add to meals or brew into a tea (in combination with other plants). Recently, it has also been reported that the species possess cardioprotective properties, antioxidant and are generally rich in vitamins and minerals [10,11,12]. Beijing: Chemical Press; 2011. Control treated group showed normal micromorphological sections. Furthermore, increased MID by the extracts could indicate macrophage formation ability and pathogenic scavenging role. Author ESA managed the literature searches and wrote the first draft of the manuscript with the assistant of FOA. Safety assessment of oral administration of ethanol extract of Justicia carnea leaf in healthy wistar rats: hematology, antioxidative and histology studies. One of the health benefits of justicia carnea is in boosting immune system. Superoxide dismutase was carried out using the method of Sun and Zigma [18]. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Google Scholar. CAS They also maintain our skin tone and texture, and help in reproductive functions. It also grows in some Caribbean islands, including Trinidad and Tobago. Except the group that received 1200mg/kg JCEE which showed significant (p<0.05) elevation of SOD and MDA in the liver, other doses (<1200mg/kg) demonstrated no significant difference compared to the control. The plant is hardy to USDA Hardiness Zones 8b through 11. According to acute toxicity grading standards, LD50 of substances greater than 5000mg/kg is practically considered non-toxic [22, 23]. what are the pros and cons of testosterone replacement therapy? The fresh leaves were thoroughly washed under running tap, air dried under shade, pulverized and extracted with ethanol. Ethanol extract of J. carnea leaf elevated red blood cell, hemoglobin, packed cell volume and platelet count with significant increase at higher doses of extracts compared to the control. They protect our cells from the harmful effects of reactive oxygen species. 217-230. Corroborating with the results of the antioxidant system and weight of the liver, continuous exposure to higher dose (1200mg/kg) of JCEE could result in hepatic damage. 2017;16(2):21730 https://doi.org/10.17306/J.AFS.2017.0492. In the kidney, SOD and MDA level were indistinguishable compared to the control except SOD level in rats that received 800mg/kg JCEE that reduced significantly (p<0.05). Hepatoprotective Effect of Methanol Extract of Justicia carnea Leaves Canadian J Appl Sci. Gas chromatography/mass spectrometry of simple coumarins, 3-phenylpropionic acids and their hydroxy and methoxy derivatives. In this article i will take you through the nutritional and medicinal benefits of justicia carnea. It may also affect the activity of hormones. Treatments of all experimental animals were performed following Principle of Laboratory Animal Care manual guidebook of National Institute of Health as approved by the Research Ethics Committee of Olusegun Agagu University of Science and Technology, Okitipupa, Ondo State. Parameter that were determined include total haemoglobin concentration (HGB), packed cell volume (PCV), red blood cell count (RBC), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC), mean corpuscular volume (MCV), white blood cell count (WBC), Lymphocyte count (LYM), MID sized cell (MID), Granulocyte Count (GRM) and platelet count (PLT). B-vitamins are good sources of energy. Liver and kidney are the main targets of toxicants because they are respectively involved in biotransformation and excretion of xenobiotics. Each rat was dissected and blood samples were collected by cardiac puncture using 5mL into tubes containing ethylenediaminetetraacetic acid (EDTA) for hematological analysis. Higher doses (>500mg/kg) of extract significantly (p<0.05) increased RBC, hemoglobin and platelet compared to the control. J Ethnopharmacol 1985;13(1):3-49. The effects of ethanol extract of J. carnea leaf on total protein concentration and antioxidant system in liver and kidney of normal wistar rat is presented in Table 4. 10.9734/ijbcrr/2020/v29i630194. He earned B.Sc. Justicia pectoralis might have many different effects in the body. Badami S, Aneesh R, Sankar S, Sathishkumar MN, Suresh B, Rajan S. Antifertility activity of Derris brevipes variety coriacea. Ewe eje isnt capable of causing any side or negative effects if consumed moderately. 4. This claim by traditional healers with regard to the efficacy of justicia carnea in the treatment diabetes have been researched on and it was found to be true. 2005 - 2023 WebMD LLC, an Internet Brands company. Tags: benefits of justicia carnea, health benefit of justicia carnea, justicia carnea . This suggested that the extract did not alter tissue function in converting harmful hydrogen peroxide to water and oxygen. Too much sun can scorch the leaves, and too little will result in fewer flowers. These antibodies help prevent infections and fight off diseases. The significant increase in MDA level at 1200mg/kg might be due to the presence of active secondary metabolites in the extracts that could have acted as prooxidant. PubMed Influence of ethanolic extracts of dried fruit of Xylopia aethiopica (Dunal) A. Generic and epigenetic contributions to human nutrition and health: managing genome-diet interactions. The aim of this study is to evaluate the safety of ethanol extract of J. carnea leaf assessing the hematology indices, organ antioxidant system and histology in healthy male wistar rats. aqueous extract J. carnea leaves and its effects on haematological and some biochemical indices of anaemia induced male Wistar albino rats. Vitamin C and E are antioxidants. Mean lethal dose of the extract was found to be above 5000mg/kg body weight (bw). Previously, J. carnea leaf has been reported to contain high quantity of phytochemical constituents (such as saponins, alkaloids and terpenoids), vitamins (A, C and E) and minerals [9, 10]. Turn off the heat and then soak the leaves into the pot. Authors TSO, KOK and ESA manage experimental protocols and performed the experiments under the supervision of FOA. 2018;2018:5762368. Effects of ethanol leaf extract of Justicia carnea on serum SOD Justicia carnea - Wikipedia Google Scholar. 32 years old (Greco et al., 1974), long-term treatment side effects are becoming more critical. Lorke D. A new approach to practical acute toxicity testing. Ewe eje is safe and healthy for consumption. It helps in replenishing blood lost during period. The result of hematology indices is presented in Table3. Haematological and biochemical studies on Justicia carnea leaves extract in phenylhydrazine induced-anemia in albino rats. What this means is that aside fighting anemia, justicia carnea leaves also improves your cardiovascular health by suppressing the tendency for dyslipidemia. In subacute study, rats were randomized into six groups of five rats per group: Group 1 (control) received distilled water, group 2, 3, 4, 5, 6 received 50, 100, 500, 800 and 1200mg/kg body weight of J. carnea ethanol extract once daily using oral gavage. WebMD does not provide medical advice, diagnosis or treatment. In these groups, from mild to severe order; shows observable congested portal vein, the liver parenchyma showed area of harmorrhage, the morphology of the hepatocytes appear pyknotic, some show mild fat infiltration (red arrow) the sinusoids appear fibrotic with infiltration of inflammatory red cells (red arrow).