I did acupuncture that cycle. Im very sorry and hope you can find the strength to continue. Setting: University-based fertility center. Im sorry to hear of your loss! She says that with PGS tested embryos my rate to achieve pregnancy is 70% and a twin pregnancy is at 50%. Best of luck to you with your upcoming FET, my thoughts and prayers are with you! A pregnancy that doesn't even make it to the 6 week scan where they can usually see the fetus on an ultrasound. A chemical pregnancy is a very early miscarriage that happens within the first five weeks of pregnancy. I have a whole page dedicated to mosaic embryos. He also answers questions in his private Facebook group. She said she is willing to do so but against her medical advice. There was also no difference with Day 7, although the sample size was very small. Be sure to read the next two sections to get an idea of how grades and growth rates (Day 5, 6, 7) affect IVF with PGS success rates, as well as this section further down. I had a chemical pregnancy last November after a fresh transfer. Advancing age of the female partner increases the chance that the embryo will be abnormal. Ive seen conflicting studies with some (irani 2017) saying poor quality euploid has just 25% LBR but some more recent studies (2021) that suggest that morphology matters more under 30 (which Im not Im 42 but was 37/8 at retrieval). Did you do anything different with your FET? Best of luck on your next FET! Dear T3BK, thank you so much for your reply! As mentioned in the study, about 72% of mosaic miscarriages occurred between observation of the gestational sac (3-5 weeks after transfer) and fetal heart beat (6-8 weeks after transfer). I pay completely out of pocket for everything so the added expense was not something I wasnt looking forward to, but Im happy I went through with it. Now I wonder if that could have been the culprit. Then another IVF/ICSI but nothing to transfer-- my doctor switched up my meds which was a bad idea obviously. I also stopped working night shifts (Im a nurse) to reduce my stress levels but that didnt help either. For more up-to-date information on this topic check out my other posts that are tagged withEmbryo rebiopsy. Note that this post is current as of July 2022. Find advice, support and good company (and some stuff just for fun). Congratulations on your success , I have a similar story. Im surprised there are still doctors out there who do not bring up this protocol. Hello- Have you ever had an endometrial biopsy to look for infection? Another small study found no difference in survival or live birth rates with rebiopsied embryos (Cimadomo et al. With both transfers I did estrogen tablets, progesterone in oil shots, blood thinner shots and low dose aspirin. Again, Im sorry if thats not helpful especially since your RE didnt think it was necessary for you but that was just my experience. Wishing you the best of luck and baby dust. Note that once you confirm, this action cannot be undone. I'm so sorry for your loss. I had been on birth control since I was 18 and had no idea what to expect when I came off it. I remember you from another post I made about only having 2 eggs fertilized you were so kind to share your story. These studies were particularly small so drawing conclusions isnt really possible yet. Or they did but they were all aneuploid? Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. For the autoimmune stuff above I was tested by Alexander Kofinas. This is important because miscarriage rates with advancing female age. I dont know if this is helpful or not but Ive had 4 FETs. I don't know how many more cycles I can do as my emotional reserve is running low. , dont be sorry! Tiegs (2020) in their multicenter prospective study transferred 414 blastocysts that were only tested using PGT-A after the pregnancy outcome. If it were me and it was my last embryo I would definitely ask about (possibly even push for) immune protocol and the ERA just to cover all my bases. Was just curious if the percentages of a live birth increase after a positive pregnancy test. I paid a fortune for those sessions (I dont have insurance). I'm glad we did - because my ERA results were abnormal and I needed 12 more hours of PIO. Patient(s): Cases included 38 patients who underwent frozen euploid ET as determined by aCGH, resulting in miscarriage. no, I just took those 3. Currently 8 weeks. END MENTS. I completely understand struggling about whether to do the 3rd retrieval, it is a lot to go through all over again. Learn more about, Learn About What to Expect's Pregnancy & Baby App. PGT-A miscarriage rates (euploid, mosaic, and aneuploid transfers) A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Don't lose hope! (2021) in their multicenter prospective trial transferred 484 euploid, 282 low mosaic (where 20-30% of the cells are aneuploid) and 131 moderate mosaic (30-50%) embryos. Embryoman (Sean Lauber) is a former embryologist and creator of Remembryo.com. I'm curious if this might have something to do with it. Overall, I really wish clinics and REs were more straightforward about odds of success esp with pgs since I think they can be a little misleading. We timed everything to my cycle. Euploid embryos are believed to have higher success rates and a reduced chance of miscarriage. If youre confused about the terminology youll see coming up, check my post on understanding PGS testing results. We decided to start with IUI with clomid which resulted in another chemical pregnancy. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. We know about the epigenetic issue from testing the sperm but its not a test that you can do on the embryos (would have to kill them), I hope you are able to figure out what is going wrong and fix it! 2nd consecutive blighted ovum with PGS normal FET. Anyone - Inspire And since then Ive had medical issues that havent allowed me to try again until last month. We got to see and hear the heartbeat yesterday. thanks for sharing! PGT-A is generally recommended for women >35, and the majority of cycles in the US in 2020 were for women >35 (62%). If you want to read more about about success rates for untested embryos, go to my embryo grading and success rates post. We did accupuncutre 2x a week prior to transfer and a pre/post on transfer day as well. More studies need to be done. END MENT And the fact that the embryo's are at least starting to implant is confusing me in relation to my lining - Does that mean that my thinner lining is OK? The ERA was about $800 and it took about 2 weeks to get the results. I had a PGT normal day 7 embryo that unfortunately resulted in a chemical. Capalbo et al. I had a chemical pregnancy with my first FET. Im going to try and run it by her again to see what she thinks. Im sorry to hear that. Tiegs (2020) in their multicenter prospective study transferred 414 blastocysts that were only tested using PGT-A after the pregnancy outcome.So no one knew what was being transferred. FAILED FIRST FET (Chemical Pregnancy). I have a Day 7/PGS Euploid They havent discontinued my medication they want me to continue until further instructions. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. Or is that the reason they don't continue to progress? That sounds a lot like my dr. Its basically an assembly line in there. I can't tell if that is from the progesterone. During my first IVF cycle, when we only created 2 normal embryos out of 18 eggs (my husband's sperm is great), it seemed like embryo quality would have explained the first two chemical pregnancies. Preimplantation Genetic Testing - RSC Bay Area I took the year off to just work on myself and be in a better mental state. RPL and endomitritis biopsy isnt a new thing, and its the same procedure as an ERA (which I also highly recommend). However, another doctor (2nd opinion) claimed that Receptiva would only be conducted for implantation failure and for those who had never seen positive pregnancy tests. We started some workup with my OB (TSH, karyotyping and carrier testing). I will talk to my dr about all of the above and hopefully i can finally get some answers :) My dr keeps pinning it on my lining but it doesnt make sense to me since Ive been over 8mm with a triple line pattern each chemical. Next Generation Sequencing (NGS) is a new technique which boasts an impressive 99.98% consistency rate for its results. However, this study did not focus on the >35 age group, which is likely to be the most benefited by this technique. Because all the women who didnt have embryos to transfer are now included and lower the overall success for that age group. Thank you! At this point I am wondering the following: The chances of having a positive outcome with PGS testing and IVF depend on the number of the produced embryos that have a positive result in the test. No PGS testing Good luck to you on this journey and I hope round 2 is successful for you!! You cant compare the per retrieval and per transfer stats against each other directly. We were told not to worry and try again after a month, and in March I found I was pregnant again but this turned out to be a chemical pregnancy. Consult with your doctor before making any treatment changes. At least testing a few variables like blood clotting. My result came with a high risk, 1 in 11 chances of the baby having Down Syndrome. 2 came back normal. So they were both frozen on Day 6? He earned his MSc in 2012 for his research on inflammation and lung cancerand started Remembryo in 2018 to help people understand the evidence behind common IVF topics. Obviously this is not an ideal situation but sometimes this happens. Does this harm the embryo or reduce its potential for success? They did blood tests after my miscarriage and my doctor said it was important to do it when my body still thought I was pregnant. I did do another round of IVF and am now 17 weeks pregnant. Have you been tested for APS (antiphosolipid syndrome)? The results came back just this week saying that I was "pre-receptive" and recommended one day more of progesterone before doing the transfer to get to a more "ideal" transfer state. He provides weekly summaries of the latest IVF research and posts on Facebook, Instagram and TikTok regularly. 2nd was an FET that was a chemical, likely due to an embryo issue, even though it was graded highest. My RE had said shes usually very cautious when it comes to sending embryos out for PGS testing only because the process can sometimes compromise the embryo itself. Looking for anyone who has had recurrent chemical pregnancies and then found success. While I know my struggles are not unique I still feel so alone in this journey. Check here for the full glossary (please excuse the repeated terms!). (2017)found no difference in survival rates of embryos that were thawed and biopsied, then refrozen. So what if the embryos are euploid? 144 abnormal (aneuploid/mosaic) embryos and their outcomes. PGT-A (formerly PGS testing) is a technique that determines the number of chromosomes in the cells of an embryo. Your clinic may have a better idea of how things work in their hands. According to the geneticist, there is as much chance it could be completely normal as the chance that it is abnormal. 35 years old Its such a good point and one that is often missed, I think. PGS or Transfer 2 embryos? - Infertility - Inspire I encourage to keep pushing forward. I know that every cycle + embryo is different, but it's so hard to not compare cycles. A chemical pregnancy is an early pregnancy loss before ultrasounds can detect a fetus.